Edit |   |
---|---|
Antigenic Specificity | PITX3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peroxidase (HRP) conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mit |
Immunogen | Immunogen: Recombinant human Pituitary homeobox 3 protein (10-200AA) |
Other Names | [Pituitary homeobox 3; Homeobox protein PITX3; Paired-like homeodomain transcription factor 3; PITX3; PTX3] |
Gene, Accession # | [PITX3], Gene ID: 5309, NCBI: NP_005020.1, UniProt: O75364 |
Catalog # | MBS7048402 |
Price | $160, $235 |
Order / More Info | PITX3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |