Parkin Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | Parkin |
| Clone | monoclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.03 mg, 0.1 mg, 0.1 mg |
| Concentration | n/a |
| Applications | Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2 (PubMed: 10973942, PubMed: 10888878, PubMed: 11431533, PubMed: 12150907, PubMed: 12628165, PubMed: 16135753, PubMed: 21376232, PubMed: 23754282, PubMed: 23620051, PubMed: 24660806, PubMed: 24751536). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context (PubMed: 19229105, PubMed: 20889974, PubMed: 25621951). Participates in the removal and/or detoxification of abnormally folded or damaged pro |
| Immunogen | Immunogen: A synthesized peptide derived from human Parkin. Subcellular Localization: Cytoplasm, cytosol. Nucleus. Endoplasmic reticulum. Mitochondrion. Mainly localizes in the cytosol. Co-localizes with SYT11 in neutrites. Co-localizes with SNCAIP in brainstem Lewy bodies. Mitochondrial localization gradually increases with cellular growth. Also relocates to dysfunctional mitochondria that have lost the mitochondrial membrane potential; recruitment to mitochondria is PINK1- dependent. Tissue Sp |
| Other Names | [E3 ubiquitin-protein ligase parkin; Parkin; 6.3.2.-; Parkinson juvenile disease protein 2; Parkinson disease protein 2; PARK2; PRKN], [PRKN; PRKN; PDJ; AR-JP; LPRS2; PARK2; Parkinson disease protein 2] |
| Gene, Accession # | [PARK2], Gene ID: 5071, NCBI: NP_004553.2, UniProt: O60260 |
| Catalog # | MBS179131 |
| Price | $160, $340, $340 |
| Order / More Info | Parkin Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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