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Antigenic Specificity | CD70 / TNFSF7 (Activated T- & B-Lymphocyte Marker) |
Clone | [BU69] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1, kappa |
Format | unconjugated |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC) Formalin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: It recognizes a protein of 30kDa, identified as CD70. It is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T- and B-lymphocytes. It induces proliferation of co-stimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. This MAb blocks the interaction between CD27 and CD70, and has been shown to inhibit T cell proliferation induced by dendritic cells. |
Immunogen | Immunogen: Human WM-1 (Waldenstrom s macroglobulinemia) cell line |
Other Names | [CD27 ligand (CD27L); CD27LG; Ki24; Surface antigen CD70; Tumor necrosis factor (ligand) superfamily, member 7 (TNFSF7)], [CD70; CD70; CD27L; CD27LG; TNFSF7; TNLG8A; CD27L; CD27LG; TNFSF7; CD27-L] |
Gene, Accession # | [CD70], Gene ID: 970, NCBI: NP_001243.1, UniProt: P32970 |
Catalog # | MBS439093 |
Price | $190, $340, $340 |
Order / More Info | CD70 / TNFSF7 (Activated T- & B-Lymphocyte Marker) Antibody from MYBIOSOURCE INC. |
Product Specific References | R.Q. Hintzen, et al, (1994) J Immunol 152: 1762-1773. M.R. Bowman, et al, (1994) J Immunol 152: 1756-1761. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1137-1138. K. Agematsu, et al, (1995) J Immunol 154: 3627-3635 |