Edit |   |
---|---|
Antigenic Specificity | ARC (CT) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | n/a |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Immunoblot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Anti-ARC (CT) [Rabbit antibody to peptide corresponding to aa 191-208 at C-terminus of human apoptosis repressor with CARD (ARC).]. This antibody recognizes full-length ARC (25 kD). Apoptosis is regulated by death domain (DD)- and/or caspase recruitment domain (CARD)-containing molecules and a caspase family of proteases. CARD domain-containing cell death regulators include RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain-containing protein was recently identified and designated ARC (apoptosis repressor with CARD). ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR- 1, and DR3. |
Immunogen | Antigen: Peptide corresponding to aa 191-208 of human ARC. |
Other Names | [ARC (CT); ARC (CT)], [ARC; ARC; Arg3.1; KIAA0278; ARC; KIAA0278] |
Gene, Accession # | Gene ID: 23237, NCBI: AAF07185.1, UniProt: Q7LC44 |
Catalog # | MBS194026 |
Price | $415 |
Order / More Info | ARC (CT) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |