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Antigenic Specificity | ITGA2B |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 693-993 of human ITGA2B (NP 000410.2). |
Other Names | [GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16; PPP1R93] |
Gene, Accession # | [ITGA2B], Gene ID: 3674, NCBI: NP_000410.2, UniProt: P08514 |
Catalog # | MBS8545716 |
Price | $280 |
Order / More Info | ITGA2B Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |