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Antigenic Specificity | Fli-1 |
Clone | [G146-22] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | unconjugated |
Size | 5 Control Slides, 0.1 mL (Concentrate), 3 ml (Prediluted) |
Concentration | n/a |
Applications | n/a |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Fli-1 protein, a member of the ETS family of DNA binding transcription factors, is involved in cellular proliferation and tumorigenesis. Approximately 90% of Ewing's Sarcoma/Primitive Neuroectodermal Tumors (ES/PNET) have a specific translocation, t(11;22)(q24;q12), which results in fusion of EWS to Fli-1, and production of an EWS-Fli-1 fusion protein, which can be detected by this antibody. Among normal tissues only endothelial cells and small lymphocytes express Fli-1. Fli-1 has been found to be expressed in the great majority of vascular tumors including Angiosarcomas, Hemangioendotheliomas, Hemangiomas, and Kaposi's Sarcomas. It has been reported that the high sensitivity and specificity of Fli-1 is equal to or exceeds that of the estab |
Immunogen | n/a |
Other Names | [FLI-1; Friend leukemia integration 1 transcription factor; Proto-oncogene Fli-1; Transcription factor ERGB], [FLI-1; FLI1] |
Gene, Accession # | [Fli-1], NCBI: CAA76731.1, UniProt: Q01543 |
Catalog # | MBS373012 |
Price | $130, $195, $205 |
Order / More Info | Fli-1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |