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Antigenic Specificity | Phospho-MAP2K1-S297 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.02 mL, 0.06 mL, 0.12 mL |
Concentration | 1mg/mL |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | MEK1 and MEK2, also called MAPK or Erk kinases, are dual-specificity protein kinases that function in a mitogen activated protein kinase cascade controlling cell growth and differentiation (1-3). Activation of MEK1 and MEK2 occurs through phosphorylation of two serine residues at positions 217 and 221, located in the activation loop of subdomain VIII, by Raf-like molecules. MEK1/2 is activated by a wide variety of growth factors and cytokines and also by membrane depolarization and calcium influx (1-4). Constitutively active forms of MEK1/2 are sufficient for the transformation of NIH/3T3 cells or the differentiation of PC-12 cells (4). MEK activates p44 and p42 MAP kinase by phosphorylating both threonine and tyrosine residues at sites loc |
Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding S297 of human MAP2K1 Observed Molecular Weight: 43kDa |
Other Names | [MEK1; MKK1; MAPKK1; PRKMK1] |
Gene, Accession # | [MAP2K1-S297] |
Catalog # | MBS2523211 |
Price | $110, $150, $225 |
Order / More Info | Phospho-MAP2K1-S297 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |