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Antigenic Specificity | MALT1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Mucosa-associated lymphoid tissue translocation gene 1 (MALT1) is a paracaspase that is a critical mediator of T-cell receptor activation of NF-kappaB and may contribute to the progression of MALT lymphomas (1-4). It contains two immunoglobulin-like domains, an amino-terminal death domain and a carboxy-terminal caspase-like domain. Association of MALT1 with Bcl-10 and CARD11/Carma1 leads to activation of IKK and subsequent stimulation of NF-kappaB, resulting in increased proliferation and inhibition of apoptosis (5, 6). A common translocation in MALT B-cell non-Hodgkin lymphomas t(11; 18)(q21; q21) results in the fusion of the amino terminus of API2 (c-IAP2), a member of the inhibitor of apoptosis protein family, to the carboxy terminus of |
Immunogen | Immunogen: Recombinant protein of human MALT1 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [DKFZp434L132; MLT; MLT1] |
Gene, Accession # | [MALT1], Gene ID: 10892, NCBI: NP_006776.1, UniProt: Q9UDY8 |
Catalog # | MBS8502026 |
Price | $310 |
Order / More Info | MALT1 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Akagi, T. et al. (1999) Oncogene 18, 5785-5794. 2. Uren, A.G. et al. (2000) Mol. Cell 6, 961-967. 3. Ruland, J. et al. (2003) Immunity 19, 749-758. 4. Nakagawa, M. et al. (2006) Leukemia 20, 929-936. 5. Che, T. et al. (2004) J. Biol. Chem. 279, 15870-15876. 6. Lucas, P.C. et al. (2001) J. Biol. Chem. 276, 19012-19019. 7. Ho, L. et al. (2005) Blood 105, 2891-2899. |