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Antigenic Specificity | MCAM |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 447-646 of human MCAM (NP 006491.2). |
Other Names | [CD146; MUC18; HEMCAM; METCAM; MelCAM] |
Gene, Accession # | [MCAM], NCBI: P43121.2, UniProt: P43121 |
Catalog # | MBS8544700 |
Price | $280 |
Order / More Info | MCAM Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |