Human DNA-(apurinic or apyrimidinic site) lyase Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityHuman DNA-(apurinic or apyrimidinic site) lyase
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman.
Isotypen/a
Formatcaprylic acid ammonium sulfate precipitate
Size0.05 mg, 0.1 mg
Concentrationn/a
ApplicationsELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Chromatin Immunoprecipitation (ChIP)
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DescriptionMultifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' ex
ImmunogenImmunogen: Recombinant Human DNA-(apurinic or apyrimidinic site) lyase Protein Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-9919 / sc-9904 / sc-55498 / sc-5572 / sc-334
Other Names[APEX nuclease; Apurinic-apyrimidinic endonuclease 1; REF-1; Redox factor-1; APEX1; APE; APE1; APEX; APX; HAP1; REF1], [APEX1; APEX1; APE; APX; APE1; APEN; APEX; HAP1; REF1; APE; APE1; APEX; APX; HAP1; REF1; APEN; AP endonuclease 1; APE-1]
Gene, Accession #[DNA], Gene ID: 328, NCBI: NP_001231178.1, UniProt: P27695
Catalog #MBS1488925
Price$160, $235
Order / More InfoHuman DNA-(apurinic or apyrimidinic site) lyase Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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