Description | Specificity: No cross reactivity with other proteins. Description: Rabbit IgG polyclonal antibody for BAT3/BAG6 detection. Tested with WB, IHC-P, IHC-F, ICC, FCM, Direct ELISA in Human; Mouse; Rat.Background: Large proline-rich protein BAT3 is a protein that in humans is encoded by the BAT3 gene. It is mapped to 6p21.33. This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants e |
Product Specific References | 1. Banerji, J., Sands, J., Strominger, J. L., Spies, T. A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain. Proc. Nat. Acad. Sci. 87: 2374-2378, 1990. 2. Hessa, T., Sharma, A., Mariappan, M., Eshleman, H. D., Gutierrez, E., Hegde, R. S. Protein targeting and degradation are coupled for elimination of mislocalized proteins. Nature 475: 394-397, 2011. 3. Mariappan, M., Li, X., Stefanovic, S., Sharma, A., Mateja, A., Keenan, R. J., Hegde, R. S. A ribosome-associating factor chaperones tail-anchored membrane proteins. Nature 466: 1120-1124, 2010. |