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Antigenic Specificity | AP-2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total AP-2 protein. Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter regio |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from human AP-2. |
Other Names | [AP-2 transcription factor; AP2A; AP2TF; TFAP2; TFAP2A] |
Gene, Accession # | [AP-2], Gene ID: 7020, NCBI: NP_001027451.1, UniProt: P05549 |
Catalog # | MBS9405886 |
Price | $200, $255 |
Order / More Info | AP-2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |