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Antigenic Specificity | Alkaline Phosphatase (Placental)/PLAP (Germ Cell Tumor Marker) |
Clone | [ALPP/2899R] |
Host Species | Rabbit |
Reactive Species | human. |
Isotype | IgG |
Format | purified |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Immunohistology (Formalin-Fixed) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Reacts with a 70kDa membrane-bound isozyme (Regan and Nagao type) of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. It is highly specific for PLAP and shows no cross-reaction with other isozymes of alkaline phosphatase. Anti-PLAP reacts with germ cell tumors and can discriminate between these and other neoplasms. Somatic neoplasms e.g. breast, gastrointestinal, prostatic, and urinary cancers may also immunoreact with antibodies to PLAP. Anti-PLAP positivity in conjunction with anti-keratin negativity favors seminoma over carcinoma. Germ cell tumors are usually anti-keratin positive, but they regularly fail to stain with anti-EMA, whereas most carcinomas stain with anti-EMA. Anti-PLAP h |
Immunogen | Immunogen: Recombinant full-length human ALPP protein Positive Control: HepG2 Cells. Placenta or seminoma |
Other Names | [Alkaline phosphatase placental type; Alkaline phosphatase Regan Isozyme; ALP; Alp1; ALPP; Germ-cell alkaline phosphatase; nagao Isozyme; PALP; Placental alkaline phosphatase 1; placental heat-stable alkaline phosphatase; PLAP-1; PLAP1] |
Gene, Accession # | [ALPP], Gene ID: 250, NCBI: NP_001623.3, UniProt: P05187 |
Catalog # | MBS4380566 |
Price | $190, $340, $340 |
Order / More Info | Alkaline Phosphatase (Placental)/PLAP (Germ Cell Tumor Marker) Antibody from MYBIOSOURCE INC. |
Product Specific References | Wick, MR, et al. 1987; Hum Pathol. 18(9):946-54. |