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Antigenic Specificity | CASP1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: CASP1 antibody detects endogenous levels of total CASP1. Description: Caspase-1, or interleukin-1 converting enzyme (ICE/ICEalpha), is a class I cysteine protease, which also includes caspases-4, -5, -11, and-12. Caspase-1 cleaves inflammatory cytokines such as pro-IL-1 and interferon-gamma inducing factor (IL-18) into their mature forms (1, 2). Like other caspases, caspase-1 is proteolytically activated from a proenzyme to produce a tetramer of its two active subunits, p20 and p10. Caspase-1 has a large amino-terminal pro-domain that contains a caspase recruitment domain (CARD). Overexpression of caspase-1 can induce apoptosis (3). Mice deficient in caspase-1, however, have no overt defects in apoptosis but do have defects in |
Immunogen | Immunogen: A synthesized peptide derived from human CASP1 Subcellular Location: Cytoplasm. Tissue Specificity: Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain. |
Other Names | [CASP-1; CASP1; CASP1_HUMAN; Caspase 1; Caspase-1 subunit p10; ICE; IL-1 beta-converting enzyme; IL-1BC; IL1 beta converting enzyme; IL1B convertase; Interleukin 1 beta convertase; Interleukin 1B converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45] |
Gene, Accession # | [CASP1], Gene ID: 834, NCBI: NP_001214.1, UniProt: P29466 |
Catalog # | MBS9606808 |
Price | $240, $280 |
Order / More Info | CASP1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |