Phospho-AKT2-S474 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | Phospho-AKT2-S474 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Akt, also referred to as PKB or Rac, plays a critical role in controlling survival and apoptosis (1-3). This protein kinase is activated by insulin and various growth and survival factors to function in a wortmannin-sensitive pathway involving PI3 kinase (2, 3). Akt is activated by phospholipid binding and activation loop phosphorylation at Thr308 by PDK1 (4) and by phosphorylation within the carboxy terminus at Ser473. The previously elusive PDK2 responsible for phosphorylation of Akt at Ser473 has been identified as mammalian target of rapamycin (mTOR) in a rapamycin-insensitive complex with rictor and Sin1 (5, 6). Akt promotes cell survival by inhibiting apoptosis through phosphorylation and inactivation of several targets, including Bad |
| Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding S474 of human AKT2 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [AKT2; PKBB; PKBBETA; PRKBB; RAC-BETA] |
| Gene, Accession # | [AKT2-S474], Gene ID: 208, NCBI: NP_001317440.1, UniProt: P31751 |
| Catalog # | MBS8527411 |
| Price | $310 |
| Order / More Info | Phospho-AKT2-S474 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Franke, T.F. et al. (1997) Cell 88, 435-7. 2. Burgering, B.M. and Coffer, P.J. (1995) Nature 376, 599-602. 3. Franke, T.F. et al. (1995) Cell 81, 727-36. 4. Alessi, D.R. et al. (1996) EMBO J 15, 6541-51. 5. Sarbassov, D.D. et al. (2005) Science 307, 1098-101. 6. Jacinto, E. et al. (2006) Cell 127, 125-37. 7. Cardone, M.H. et al. (1998) Science 282, 1318-21. 8. Brunet, A. et al. (1999) Cell 96, 857-68. 9. Zimmermann, S. and Moelling, K. (1999) Science 286, 1741-4. 10. Cantley, L.C. and Neel, B.G. (1999) Proc Natl Acad Sci USA 96, 4240-5. 11. Vlahos, C.J. et al. (1994) J Biol Chem 269, 5241-8. 12. Hajduch, E. et al. (2001) FEBS Lett 492, 199-203. 13. Cross, D.A. et al. (1995) Nature 378, 785-9. 14. Diehl, J.A. et al. (1998) Genes Dev 12, 3499-511. 15. Gesbert, F. et al. (2000) J Biol Chem 275, 39223-30. 16. Zhou, B.P. et al. (2001) Nat Cell Biol 3, 245-52. 17. Nave, B.T. et al. (1999) Biochem J 344 Pt 2, 427-31. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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