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Antigenic Specificity | (Mouse) Suz12 (Center) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This mouse Suz12 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 381-395 amino acids from the Central region of mouse Suz12. Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. |
Immunogen | n/a |
Other Names | [Polycomb protein Suz12; Suppressor of zeste 12 protein homolog; Suz12; D11Ertd530e; Kiaa0160] |
Gene, Accession # | [Suz12], Gene ID: 52615, NCBI: NP_001156490.1, UniProt: Q80U70 |
Catalog # | MBS9203218 |
Price | $165, $370 |
Order / More Info | (Mouse) Suz12 (Center) Antibody from MYBIOSOURCE INC. |
Product Specific References | Okazaki N.,et al.DNA Res. 10:35-48(2003). Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009). Pasini D.,et al.EMBO J. 23:4061-4071(2004). Umlauf D.,et al.Nat. Genet. 36:1296-1300(2004). Kuzmichev A.,et al.Proc. Natl. Acad. Sci. U.S.A. 102:1859-1864(2005). |