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Antigenic Specificity | TNFAIP3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human TNFAIP3 (NP 006281.1). |
Other Names | [A20; AISBL; OTUD7C; TNFA1P2] |
Gene, Accession # | [TNFAIP3], Gene ID: 7128, NCBI: NP_001257436.1, UniProt: P21580 |
Catalog # | MBS8549151 |
Price | $280 |
Order / More Info | TNFAIP3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |