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Antigenic Specificity | NT5E |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.06 mL, 0.12 mL, 0.2 mL |
Concentration | 1mg/mL |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Ecto-5'nucleotidase (NT5E, also called CD73) is a 70 kDa glycosyl phosphatidylinositol-anchored membrane-bound glycoprotein that catalyzes the hydrolysis of extracellular nucleoside monophosphates into bioactive nucleoside (1). NT5E catalyzes the terminal step of extracellular adenosine formation from adenosine-monophosphate, therefore driving the regulation of extracellular adenosine levels and the downstream activation of the four G protein-coupled adenosine receptors (2). Binding of hypoxia-inducible factor (HIF-1) to the NT5E gene promotor leads to upregulation of NT5E during hypoxia (3). NT5E biological roles span from lymphocyte adhesion (4, 5), to fibrosis (6), to regulation of nociception (7, 8). |
Immunogen | Immunogen: Recombinant protein of human NT5E Observed Molecular Weight: 63kDa |
Other Names | [CD73; E5NT; NT; NT5; NTE; eN; Ent] |
Gene, Accession # | [NT5E], Gene ID: 4907, NCBI: AAH15940.1 |
Catalog # | MBS2524904 |
Price | $150, $225, $360 |
Order / More Info | NT5E Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |