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Antigenic Specificity | c-Cbl (Tyr-700), phospho-specific |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | human, rat, mouse |
Isotype | IgG1 |
Format | Protein A purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects a 120 kDa* protein in human Jurkat cells treated with pervanadate, but not in control cells. c-Cbl proto-oncogene is a ubiquitously expressed cytoplasmic adaptor protein that is especially predominant in hematopoietic cells. c-Cbl possesses a highly conserved amino-terminal phosphotyrosine binding domain and a C3HC4 RING finger motif. c-Cbl is rapidly tyrosine phosphorylated in response to stimulation of a variety of cell-surface receptors and becomes associated with a number of intracellular signaling molecules such as protein tyrosine kinases, phosphatidylinositol 3 kinase (PI3K), Crk and 14-3-3 proteins. In human cancer tissues, c-Cbl is frequently tyrosine phosphorylated in a tumor-specific manner. Src-family kinase |
Immunogen | Immunogen: Clone (M161) was generated from a synthetic peptide (coupled to KLH) corresponding to amino acid residues surrounding tyrosine 700 in human c-Cbl. This sequence is highly conserved in rat and mouse c-Cbl. |
Other Names | [c-Cbl (Tyr-700); phospho-specific; E3 ubiquitin-protein ligase CBL; RING finger protein 55], [CBL; CBL; CBL2; NSLL; C-CBL; RNF55; CBL2; RNF55] |
Gene, Accession # | Gene ID: 867, UniProt: P22681 |
Catalog # | MBS470006 |
Price | $385 |
Order / More Info | c-Cbl (Tyr-700), phospho-specific Antibody from MYBIOSOURCE INC. |
Product Specific References | • Blake, T. J. et al. (1991) Oncogene 6:653.• Donovan, J.A., et al. (1994) J. Biol. Chem. 269:37.• Rivero-Lezcano, O.M. et al. (1994) J. Biol. Chem. 269:26.• Christine, B. F. et al. (2001) Nat. Rev. Mol. Cell Biol. 2:294. |