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Antigenic Specificity | VRK1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 0.8mg/ml |
Applications | Immunohistochemistry (IHC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total VRK1 protein. This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. |
Immunogen | Immunogen: Fusion protein of human VRK1 Immunogen Type: Protein |
Other Names | [PCH1; PCH1A] |
Gene, Accession # | [VRK1], Gene ID: 7443, NCBI: NP_003375.1, UniProt: Q99986 |
Catalog # | MBS9417014 |
Price | $255 |
Order / More Info | VRK1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |