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Antigenic Specificity | RAN |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Ran is a small GTPase of the Ras family that plays a central role in the spacial and temperal organization of eukaryotic cells. During interphase, Ran-GDP localizes to the cytoplasm and Ran-GTP to the nucleus. This polarized localization of Ran ensures its role in nuclear transport (1). During mitosis, Ran-GTP is chromatin associated, where it promotes spindle assembly and nuclear envolope formation (1, 2). In S phase, Ran-GTP associates with and inhibits MCM helicase, ensuring precise chromosomal DNA duplication during the cell cycle (3). |
Immunogen | Immunogen: Recombinant protein of human RAN Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [RAN; ARA24; Gsp1; TC4] |
Gene, Accession # | [RAN], Gene ID: 5901, NCBI: NP_001287725.1, UniProt: P62826 |
Catalog # | MBS8502463 |
Price | $310 |
Order / More Info | RAN Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Quimby, B.B. and Dasso, M. (2003) Curr. Opin. Cell Biol. 15, 338-344. 2. Hetzer, M. et al. (2002) Nat. Cell Biol. 4, 177-184. 3. Yamaguchi, R. and Newport, J. (2003) Cell 113, 115-125. |