EGLN3 (C-term), 203-231 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | EGLN3 (C-term), 203-231 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human (predicted reactivity: mouse, rat) |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.5 |
| Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This EGLN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 203-231 amino acids from the C-terminal region of human EGLN3. EGLN3 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. May play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. Promotes cell death through a caspase-dependent mechanism (By similarity). |
| Immunogen | n/a |
| Other Names | [Egl nine homolog 3; HPH-1; Hypoxia-inducible factor prolyl hydroxylase 3; HIF-PH3; HIF-prolyl hydroxylase 3; HPH-3; Prolyl hydroxylase domain-containing protein 3; PHD3; EGLN3] |
| Gene, Accession # | [EGLN3], Gene ID: 112399, NCBI: NP_071356.1, UniProt: Q9H6Z9 |
| Catalog # | MBS9203544 |
| Price | $165, $370 |
| Order / More Info | EGLN3 (C-term), 203-231 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Sato, M., et al. Exp. Cell Res. 316(17):2871-2882(2010) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Xue, J., et al. Gastroenterology 138(2):606-615(2010) Henze, A.T., et al. Cancer Res. 70(1):357-366(2010) Hatzimichael, E., et al. Eur. J. Haematol. 84(1):47-51(2010) |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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