Phospho-Tyr1325 NMDA NR2A-Subunit Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-Tyr1325 NMDA NR2A-Subunit |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Specific for the ~180k NMDAR NR2A-subunit protein phosphorylated at Tyr1325 in Western blots. Immunolabeling is completely blocked by blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide. Affinity purified rabbit polyclonal antibody |
| Immunogen | Antigen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Tyr1325 of rat NMDA NR2A. Immunogen Information: Synthetic phospho-peptide corresponding to amino acid residues surrounding Tyr1325 conjugated to KLH. Immunogen Species: Rat |
| Other Names | [glutamate receptor ionotropic, NMDA 2A; Glutamate receptor ionotropic, NMDA 2A; glutamate receptor ionotropic, NMDA 2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor subunit 2A; glutamate [NMDA] receptor subunit epsilon-1; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; Glutamate [NMDA] receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A], [Grin2a; Grin2a; NR2A; GluN2A; NMDAR2A; GluN2A; NMDAR2A; NR2A] |
| Gene, Accession # | [GRIN2A], Gene ID: 24409, NCBI: NP_036705.3, UniProt: Q00959 |
| Catalog # | MBS502160 |
| Price | $360 |
| Order / More Info | Phospho-Tyr1325 NMDA NR2A-Subunit Antibody from MYBIOSOURCE INC. |
| Product Specific References | • Alvestad RM, Grosshans DR, Coultrap SJ, Nakazawa T, Yamamoto T, Browning MD (2003)Tyrosine dephosphorylation and ethanol inhibition of N-methyl-D-aspartate receptor function. J Biol Chem 278:11020-11025.• Carroll RC, Zukin RS (2002) NMDA-receptor trafficking and targeting: implications for synaptic transmission and plasticity. Trends Neurosci 25:571-577.• Grosshans DR, Clayton DA, Coultrap SJ, Browning MD (2002) LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1. Nat Neurosci 5:27-33. Ishii T, Moriyoshi K, Sugihara H, Sakurada K, Kadotani H, Yokoi M, Akazawa C, Shigemoto R, Mizuno N, Masu M, Nakanishi S (1993) Molecular characterization of the family of the N-methyl- D-aspartate receptor subunits. J Biol Chem 268:2836-2843. Lovinger DM, White G, Weight FF (1989) Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science 243:1721-1724. Snell LD, Nunley KR, Lickteig RL, Browning MD, Tabakoff B, Hoffman PL (1996) Regional and subunit specific changes in NMDA receptor mRNA and immunoreactivity in mouse brain following chronic ethanol ingestion. Mol Brain Res 40:71-78. Wenthold RJ, Prybylowski K, Standley S, Sans N, Petralia RS (2003) Trafficking of NMDA receptors. Annu Rev Pharmacol Toxicol 43:335-358. King JE, Eugenin EA, Hazleton JE, Morgello S, Berman JW (2010) Mechanisms of HIV-tat-induced phosphorylation of N-methyl-D-aspartate receptor subunit 2A in human primary neurons: implications for neuroAIDS pathogenesis. Am J Pathol. 176(6):2819-30.• Taniguchi S, Nakazawa T, Tanimura A, Kiyama Y, Tezuka T, Watabe AM, Katayama N, Yokoyama K, Inoue T, Izumi-Nakaseko H, Kakuta S, Sudo K, Iwakura Y, Umemori H, Inoue T, Murphy NP, Hashimoto K, Kano M, Manabe T, Yamamoto T. (2009) Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour. EMBO J. 28(23):3717-29. |
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