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Antigenic Specificity | Human CD80 |
Clone | [4A2D10.4] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | fluorescein (FITC) conjugate |
Size | 50 tests, 100 tests |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD80, also known as B7-1, B7, and BB1, is a 60 kD single chain type I glycoprotein belonging to the immunoglobulin superfamily. CD80 is expressed on activated B and T cells, macrophages, and dendritic cells. CD80 binds to CD28 and CD152 (CTLA-4). Along with CD86, CD80 plays a critical role in regulation of T cell activation. The interaction of CD80 with CD28 provides a potent costimulatory signal for T cell activation through the CD3 complex, while its interaction with CTLA-4 provides an inhibitory signal for T cell activation. |
Immunogen | n/a |
Other Names | [T-lymphocyte activation antigen CD80; T-lymphocyte activation antigen CD80; CD80 molecule] |
Gene, Accession # | [CD80], Gene ID: 768950, NCBI: NP_001073207.1 |
Catalog # | MBS8502756 |
Price | $215, $280 |
Order / More Info | Human CD80 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. You CX et al., (2012) Oncoimmunology 1(6):847-855. 2. Gibbons RM et al., (2012) Oncoimmunology 1(7):1061-1073. 3. Garufi A et al., (2012) PLoS One 7(11):e48342. |