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Antigenic Specificity | Cish |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | n/a |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
Immunogen | Immunogen: Cish antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the C-terminal of human CISH, identical to the related rat and Rabbit sequences, as the immunogen |
Other Names | [Affinity Purified Rabbit Cish; Cish; Cish; cytokine inducible SH2-containing protein; Cis; F17; F23; CIS1; AI385595] |
Gene, Accession # | [Cish] |
Catalog # | MBS5313070 |
Price | $345 |
Order / More Info | Cish Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |