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Antigenic Specificity | MUTYH |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total MUTYH antibody. Base excision repair (BER) proteins catalyze the removal of incorrect or damaged bases, including oxidized bases, from DNA. N-glycosylases specific to a given lesion remove the incorrect base as the first step in BER. MYH is the mammalian ortholog of E. coli MutY, a DNA glycosylase that catalyzes the removal of 8-oxoG:A mismatches (1). Several MYH isoforms have been detected in human cells localizing to either the nucleus or the mitochondria (2). MYH interacts with DNA repair proteins and localizes to DNA damage foci after oxidative damage (3). Research studies have shown that mutations in the corresponding MYH gene are associated with human gastric (4) and colorectal (5-7) canc |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human MUTYH. |
Other Names | [MGC4416; MYH] |
Gene, Accession # | [MUTYH], Gene ID: 4595, NCBI: NP_001041636.1, UniProt: Q9UIF7 |
Catalog # | MBS9410781 |
Price | $255 |
Order / More Info | MUTYH Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |