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Antigenic Specificity | Klotho (C-term) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | unconjugated |
Size | 0.05 mL, 0.2 mL |
Concentration | n/a |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This Klotho antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 284-315 amino acids from the C-terminal region of human Klotho. May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). |
Immunogen | n/a |
Other Names | [Klotho; 3.2.1.31; Klotho peptide; KL] |
Gene, Accession # | [KL], Gene ID: 9365, NCBI: NP_004786.2, UniProt: Q9UEF7 |
Catalog # | MBS9217294 |
Price | $165, $370 |
Order / More Info | Klotho (C-term) Antibody from MYBIOSOURCE INC. |
Product Specific References | Kuro-o M.,et al.Nature 390:45-51 (1997). Matsumura Y.,et al.Biochem. Biophys. Res. Commun. 242:626-630 (1998). Dunham A.,et al.Nature 428:522-528 (2004). Kato Y.,et al.Biochem. Biophys. Res. Commun. 267:597-602 (2000). Yahata K.,et al.J. Mol. Med. 78:389-394 (2000). |