Apaf-1 (A15) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Apaf-1 (A15) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.2 mg |
| Concentration | 0.200 mg/ml |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Human Apaf-1. Large multi-protein complexes known as the DISC (death inducing signalling complex) and the apoptosome activate the normally inactive caspases through proteolytic processing (1). The formation of these complexes leads to the activation of caspases and the execution of apoptosis (1,2). The apoptosome is a large 700 or 1400 kDa protein complex comprised of Apaf-1 (apoptotic protease activating factor-1), cytochrome c, and dATP (1). Apaf-1 and cytochrome c in the presence of dATP leads to the oligomerization of Apaf-1 and the formation of either the 700 or 1400 kDa complexes (3&4). Once formed the apoptosome activates caspase-9, which in turn activates the effector caspases (1&5). Some researchers have found the 700 |
| Immunogen | Immunogen: Synthetic peptide mapping at the amino terminal domain of human PCNA |
| Other Names | [Apoptotic protease-activating factor 1; Apoptotic protease-activating factor 1; apoptotic protease-activating factor 1; apoptotic peptidase activating factor 1], [APAF1; APAF1; CED4; APAF-1; KIAA0413; APAF-1] |
| Gene, Accession # | [Apaf-1], Gene ID: 317, NCBI: O14727.2, UniProt: O14727 |
| Catalog # | MBS440041 |
| Price | $240 |
| Order / More Info | Apaf-1 (A15) Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Cain K., Bratton S.B., Cohen G.M. 2002. The Apaf-1 apoptosome: a large caspase-activating complex. Biochimie 84 (2-3):203-214.2. Bratton S.B., Lewis J., Butterworth M., Duckett C.S., Cohen G.M. 2002. XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis. Cell Death Differ 9(9):881-892.3. Bratton S.B., Walker G., Roberts D.L., Cain K., Cohen G.M. 2001. Caspase-3 cleaves Apaf-1 into an ~30kDa fragment that associates with an inappropriately oligomerized and biologically inactive ~1.4 Mda apoptosome complex. Cell Death Differ 8(4):425-433.4. Cain K., Bratton S.B., Langlais C., Walker G., Brown D.G., Sun X.M., Cohen G.M. 2000. Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-Mda apoptosome complex. J Biol Chem 275(9):6067-6070.5. Zou H., Li Y., Liu X., Wang X. 1999. An Apaf-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem 274(17):11549-11556.6. Robles A.I., Bemmels N.A., Foraker A.B., Harris C.C. 2001. Apaf-1 is a transcriptional target of p53 in DNA damage-induced apoptosis. Cancer Res 61(18):6660-6664. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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