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Antigenic Specificity | Hsp70 |
Clone | [5A5] |
Host Species | Mouse |
Reactive Species | human, mouse, rat, amphibians, chicken, fish, Fruit Fly, yeast |
Isotype | IgG1 |
Format | peroxidase (HRP) conjugate |
Size | 0.1 mg |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Antibody Microarray (AM) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Detects ~70kDa. May detect HSP70, HSC70, Grp78 and HSP72. Background: HSP70 genes encode abundant heat-inducible 70-kDa HSPs (HSP70s). In most eukaryotes HSP70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplasmic reticulum and the cytosol, as well as in bacteria. The genes show a high degree of conservation, having at least 50% identity (2). The N-terminal two thirds of HSP70s are more conserved than the C-terminal third. HSP70 binds ATP with high affinity and possesses a weak ATPase activity which can be stimulated by binding to unfolded proteins and synthetic peptides (3). When HSC70 (constitutively expressed) present in mammalia |
Immunogen | Immunogen: Human recombinant HSP70 overexpressed in E.coli. Cellular Localization: Cytoplasm |
Other Names | [Hsp70 1; Hsp70 2; Hsp70.1; Hsp72; HSPA1; HSPA1A; HSPA1B], [HSPA1A; HSPA1A; HSP72; HSPA1; HSP70I; HSP70-1; HSP70-1A; HEL-S-103; HSPA1; HSX70HSPA1B; HSP70-1/HSP70-2; HSP70.1/HSP70.2] |
Gene, Accession # | Gene ID: 3303, NCBI: NP_005336.3, UniProt: P08107 |
Catalog # | MBS804384 |
Price | $405 |
Order / More Info | Hsp70 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Balashova N. et al. (2005) J Biol Chem 280:2186-96. 2. Boorstein W. R., Ziegelhoffer T. & Craig E. A. (1993) J. Mol. Evol.38 (1): 1-17. 2. Rothman J. (1989) Cell 59: 591 -601. 3. DeLuca-Flaherty et al. (1990) Cell 62: 875-887. 4. Bork P., Sander C. & Valencia A. (1992) Proc. Nut1 Acad. Sci. USA 89: 7290-7294. 5. Fink A.L. (1999) Physiol. Rev. 79: 425-449. |