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Antigenic Specificity | APC |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. |
Immunogen | Immunogen: A synthesized peptide derived from human APC |
Other Names | [APC; APC protein; Adenomatous polyposis coli protein; DP2.5; mAPC] |
Gene, Accession # | [APC], Gene ID: 324, NCBI: NP_000029.2, UniProt: P25054 |
Catalog # | MBS8542661 |
Price | $280 |
Order / More Info | APC Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |