Mouse Xaf1 (Center), 166-194 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Mouse Xaf1 (Center), 166-194 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.5 |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This Mouse Xaf1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-194 amino acids from the Central region of mouse Xaf1. Xaf1 seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytop |
| Immunogen | n/a |
| Other Names | [XIAP-associated factor 1; BIRC4-binding protein; Xaf1; Birc4bp; Xiapaf1] |
| Gene, Accession # | [Xaf1], Gene ID: 327959, NCBI: NP_001032802.2, UniProt: Q5NBU8 |
| Catalog # | MBS9212846 |
| Price | $165, $370 |
| Order / More Info | Mouse Xaf1 (Center), 166-194 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Bai, Y., et al. J. Biol. Chem. 283(11):6832-6842(2008) Qiao, L., et al. Tumour Biol. 29(2):122-129(2008) Wang, X., et al. Neurobiol. Dis. 16(1):179-189(2004) Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003) |
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