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Antigenic Specificity | DCC - middle region |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | dog, guinea pig, horse, human, mouse, rabbit, rat, zebrafish |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This is a rabbit polyclonal antibody against DCC. It was validated on Western BlotTarget Description: This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. |
Immunogen | Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human DCC |
Other Names | [netrin receptor DCC; Netrin receptor DCC; netrin receptor DCC; DCC netrin 1 receptor; Colorectal cancer suppressor; Immunoglobulin superfamily DCC subclass member 1; Tumor suppressor protein DCC] |
Gene, Accession # | [DCC], Gene ID: 1630, NCBI: NP_005206, UniProt: P43146 |
Catalog # | MBS3208253 |
Price | $365 |
Order / More Info | DCC - middle region Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |