APAF-1-ALT Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | APAF-1-ALT |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.05 mL, 0.1 mL |
| Concentration | 1.0 mg/ml |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The antibody detects endogenous levels of total APAF-1-ALT protein. This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.Keigo Machida, J. Biol. Chem., Apr 2001; 276: 12140 - 12146.Liam O!?Connor, Cancer Res., Mar 2000; 60: 1217 - 1220.Zeping Wang, |
| Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from human APAF-1-ALT. |
| Other Names | [APAF1-interacting protein; APIP; APIP2; CGI-29 protein; MMRP19] |
| Gene, Accession # | [APAF-1-ALT], Gene ID: 317, NCBI: NP_001151.1, UniProt: O14727 |
| Catalog # | MBS9406077 |
| Price | $200, $255 |
| Order / More Info | APAF-1-ALT Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
Profile of MYBIOSOURCE INC.
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