TNF-RII, Human Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | TNF-RII, Human |
| Clone | 80M2 |
| Host Species | Mouse |
| Reactive Species | human, rat |
| Isotype | IgG1 |
| Format | unconjugated |
| Size | 0.5 mg |
| Concentration | n/a |
| Applications | Flow Cytometry (FC/FACS), Functional Studies (FS), Immuno Assay (IA), Immunofluorescence (IF), Immunoprecipitation (IP) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The monoclonal antibody 80M2 recognizes the extracellular part of- membrane-bound TNF-RII as well as- the soluble form of TNF-RII which is generated by proteolytic cleavage of the extracellular domain. The soluble form can still bind TNF-alpha with high affinity and functions as a TNF-alpha antagonist.- TNF-alpha is an important signaling protein in the immune system which can activate inflammatory responses, induce apoptosis, regulate cellular proliferation, and may even promote cancer progression. TNF-alpha can bind to two structurally distinct membrane receptors, TNF-RI and TNF-RII, which have both distinct and overlapping downstream signaling cascades. TNFRI is believed to be expressed on nearly all cell types, whereas TNFRII exhibits m |
| Immunogen | n/a |
| Other Names | [Tumor necrosis factor receptor superfamily member 1B; CD120b; TNF-R2; p75; p80 TNF-alpha receptor], [TNFRSF1B; TNFRSF1B; p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II; TNFBR; TNFR2; TNF-R2; TNF-RII; TNFR-II] |
| Gene, Accession # | [TNF-RII], Gene ID: 7133, NCBI: NP_001057.1, UniProt: P20333 |
| Catalog # | MBS584732 |
| Price | $1665 |
| Order / More Info | TNF-RII, Human Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Grell, M et al; The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. Cell 1995, 83: 793 2. Till, A et al; The Met 196 - Arg variation of human tumor necrosis factor receptor 2 (TNFR2) affects TNF-alpha induced apoptosis by impaired NF-kB signalling and target gene expression. J Biol Chem 2005, 280: 5994 3. Scherubl C. et al; Colocalization of endogenous TNF with a functional intracellular splice form of human TNF receptor type 2. Journal of Inflammation 2005, 2: 7 4. Krippner, A et al; Single chain TNF, a TNF derivative with enhanced stability and antitumoral activity. J Immunol 2008, 180: 8176 5. Fairfax, B et al; A common haplotype of the TNF receptor 2 gene modulates endotoxin tolerance. J. Immonol 2011, 186: 3058 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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