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Antigenic Specificity | LRP6 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-325 of human LRP6 (NP 002327.2). |
Other Names | [ADCAD2; STHAG7] |
Gene, Accession # | [LRP6], Gene ID: 4040, NCBI: NP_002327.2, UniProt: O75581 |
Catalog # | MBS8548938 |
Price | $280 |
Order / More Info | LRP6 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |