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Antigenic Specificity | FADD - middle region |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. |
Immunogen | Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human FADD |
Other Names | [FAS-associated death domain protein; Protein FADD; FAS-associated death domain protein; Fas associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; Growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity] |
Gene, Accession # | [FADD], Gene ID: 8772, NCBI: NP_003815.1, UniProt: Q13158 |
Catalog # | MBS3223079 |
Price | $335 |
Order / More Info | FADD - middle region Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |