SIVA Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | SIVA |
| Clone | polyclonal |
| Host Species | Chicken |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mg |
| Concentration | 1 mg/mL |
| Applications | ELISA (EIA), Western Blot (WB), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | SIVA Antibody: SIVA plays an important role in the apoptotic pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. SIVA is a small cysteine-rich protein with a unique N-terminal amphipathic helical region, a death domain homology region (DDHR) and a C-terminal cysteine-rich B-box-like or zinc-finger-like structure. The DDHR domain binds to CD27 and induces apoptosis in T cells through a caspase-dependent mitochondrial pathway. SIVA inhibits BCL2L1 isoform Bcl-xL anti-apoptotic activity and inhibits activation of NFκ-B and promotes T-cell receptor-mediated apoptosis. SIVA represents a potential therapeutic target for the treatment of neuronal cell death diseases. |
| Immunogen | Immunogen: SIVA antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human SIVA. Buffer: SIVA Antibody is supplied in PBS containing 0.02% sodium azide. |
| Other Names | [SIVA; SIVA; CD27BP; Siva-1; Siva-2; SIVA; Apoptosis regulatory protein Siva; CD27-binding protein; SIVA1, apoptosis-inducing factor], [SIVA1; SIVA1; SIVA; CD27BP; Siva-1; Siva-2; SIVA; CD27BP] |
| Gene, Accession # | [SIVA1], Gene ID: 10572, NCBI: NP_068355, UniProt: O15304 |
| Catalog # | MBS150365 |
| Price | $375 |
| Order / More Info | SIVA Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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