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Antigenic Specificity | SIGIRR |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. |
Immunogen | Immunogen: Recombinant human Single Ig IL-1-related receptor protein (N-120AA) |
Other Names | [Single Ig IL-1-related receptor; Single Ig IL-1R-related molecule; Single immunoglobulin domain-containing IL1R-related protein; Toll/interleukin-1 receptor 8; TIR8; SIGIRR; UNQ301/PRO342] |
Gene, Accession # | [SIGIRR], Gene ID: 59307, NCBI: NP_001128525.1, UniProt: Q6IA17 |
Catalog # | MBS7046480 |
Price | $120, $160 |
Order / More Info | SIGIRR Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |