Edit |   |
---|---|
Antigenic Specificity | PADI4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 374-550 of human PADI4 (NP 036519.2). |
Other Names | [PAD; PAD4; PDI4; PDI5; PADI5] |
Gene, Accession # | [PADI4], Gene ID: 23569, NCBI: Q9UM07.2, UniProt: Q9UM07 |
Catalog # | MBS8550273 |
Price | $280 |
Order / More Info | PADI4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |