Edit |   |
---|---|
Antigenic Specificity | Human CD45RA |
Clone | [HI100] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2b |
Format | unconjugated |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD45RA is a 205-220 kD single chain type I glycoprotein. It is an exon 4 splice variant of the tyrosine phosphatase CD45. The CD45RA isoform is expressed on resting/naive T cells, medullary thymocytes, B cells and monocytes. CD45RA enhances both T cell receptor and B cell receptor signaling. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. CD45 has also been reported to bind galectin-1. CD45 isoform expression can change in response to cytokines. |
Immunogen | n/a |
Other Names | [Human CD45RA; Receptor-type tyrosine-protein phosphatase C; Ptprc; L-CA; Ly-5; T200; CD45] |
Gene, Accession # | [CD45RA], Gene ID: 5788, NCBI: NP_002829.3, UniProt: P08575 |
Catalog # | MBS2553833 |
Price | $60, $100 |
Order / More Info | Human CD45RA Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Thomas M. 1989. Annu. Rev. Immunol. 7:339. 2. Trowbridge I, et al. 1994. Annu. Rev. Immunol.12:85. |