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Antigenic Specificity | p53 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat, dog, rabbit |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | 500 ug/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | p53, a 53 kDa protein, binds to a DNA consensus sequence, the p53 response element, and regulates normal cell cycle events by activating transcription of genes involved either in progression through the cell cycle, or causing arrest in G1 when the genome is damaged. In most transformed and tumor cells the concentration of p53 is increased 5 1000 fold over the concentration in normal cells, principally due to the increased half life (4 hrs) compared to that of wild type (20 min). p53 localizes in the nucleus, but is detectable at the plasma membrane during mitosis and certain mutations also modulate cytoplasmic/nuclear distribution. p53 downregulates Bcl 2 expression and upregulates Bax expression, but may not always be necessary for apoptos |
Immunogen | Immunogen: p53 antibody was raised in Rabbit using synthetic peptide corresponding to residue surrounding amino acid 375 of human p53 as the immunogen. |
Other Names | [Rabbit p53; p53; p53; p53 Oncoprotein; p53; p 53; p-53; p 53; p-53] |
Gene, Accession # | [p53], Gene ID: 7157, NCBI: BAC16799.1 |
Catalog # | MBS5309044 |
Price | $705 |
Order / More Info | p53 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |