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Antigenic Specificity | NBN |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | NBN, also named as NBS, NBS1 and P95, is a component of the MRE11/RAD50/NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. NBN also functions in telomere length maintenance by generating the 3' o |
Immunogen | Immunogen: A synthetic peptide of human NBN Calculated Molecular Weight: 85kDa |
Other Names | [p95; NBS1: AT-V1; AT-V2; ATV; FLJ10155; MGC87362; NBS; NBS1; P95], [NBN; NBN; ATV; NBS; P95; NBS1; AT-V1; AT-V2; NBS; NBS1; P95] |
Gene, Accession # | [NBN], Gene ID: 4683, NCBI: O60934.1, UniProt: O60934 |
Catalog # | MBS126046 |
Price | $200, $275, $430 |
Order / More Info | NBN Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |