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Antigenic Specificity | AGER |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 30-330 of human AGER (NP 001127.1). |
Other Names | [RAGE; SCARJ1] |
Gene, Accession # | [AGER], Gene ID: 177, NCBI: NP_001193895.1, UniProt: Q15109 |
Catalog # | MBS8544382 |
Price | $280 |
Order / More Info | AGER Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |