Bit1 (Center), 80-110 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Bit1 (Center), 80-110 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.5 |
| Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This Bit1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-110 amino acids from the Central region of human Bit1. Adhesion to extracellular matrix regulates cell survival via integrin engagement and cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment. A role for Bit1 (Bcl-2 inhibitor of transcription 1) has been identified in this process. Bit1 is a mitochondrial protein released into the cytoplasm upon onset of apoptosis where it forms a complex with AES, a small Groucho/transducin-like enhancer of split (TLE) protein and induces caspase-independent apoptosis. AES and TLE proteins are transcriptional co-repressors that play important roles in neuroge |
| Immunogen | n/a |
| Other Names | [Peptidyl-tRNA hydrolase 2; mitochondrial; PTH 2; Bcl-2 inhibitor of transcription 1; PTRH2; BIT1; PTH2] |
| Gene, Accession # | [PTRH2], Gene ID: 51651, NCBI: NP_057161.1, UniProt: Q9Y3E5 |
| Catalog # | MBS9214490 |
| Price | $165, $370 |
| Order / More Info | Bit1 (Center), 80-110 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Cell 116(5):751-762 (2004). Biochim Biophys Acta. 1692:145-57 (2004). Gene 2000; 249:1-16. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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