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Antigenic Specificity | FAS |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total Fas protein. Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).Michael J. Pinkoski, Am JPhysiol Gastrointest Liver Physiol, Mar 2000; 278: 354. Morgan Jenkins, J. Immunol., Aug 1999; 163: 1195. Nicholas Mitsiades, J Natl Cancer Inst, Oct 1999; 91 |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from C-terminal of human Fas. |
Other Names | [Apo-1; CD95; FasL receptor; TNFRSF6; TNR6] |
Gene, Accession # | [FAS], Gene ID: 355, NCBI: NP_000034.1, UniProt: P25445 |
Catalog # | MBS9409278 |
Price | $200, $255 |
Order / More Info | FAS Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |