FAS Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityFAS
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formatimmunogen affinity purified
Size0.05 mL, 0.1 mL
Concentration1.0 mg/ml
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC)
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DescriptionThe antibody detects endogenous levels of total Fas protein. Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).Michael J. Pinkoski, Am JPhysiol Gastrointest Liver Physiol, Mar 2000; 278: 354. Morgan Jenkins, J. Immunol., Aug 1999; 163: 1195. Nicholas Mitsiades, J Natl Cancer Inst, Oct 1999; 91
ImmunogenImmunogen Type: Peptide Immunogen Description: Synthesized peptide derived from C-terminal of human Fas.
Other Names[Apo-1; CD95; FasL receptor; TNFRSF6; TNR6]
Gene, Accession #[FAS], Gene ID: 355, NCBI: NP_000034.1, UniProt: P25445
Catalog #MBS9409278
Price$200, $255
Order / More InfoFAS Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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