Human 26S proteasome non-ATPase regulatory subunit 10 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Human 26S proteasome non-ATPase regulatory subunit 10 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | biotin conjugate |
| Size | 0.05 mg, 0.1 mg |
| Concentration | n/a |
| Applications | ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis. Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by |
| Immunogen | Immunogen: Recombinant human 26S proteasome non-ATPase regulatory subunit 10 protein(1-226AA) Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-28479 / sc-8991 |
| Other Names | [26S proteasome regulatory subunit p28; Gankyrin; p28(GANK); PSMD10], [PSMD10; PSMD10; p28; p28(GANK); dJ889N15.2] |
| Gene, Accession # | [PSMD10], Gene ID: 5716, NCBI: NP_002805.1, UniProt: O75832 |
| Catalog # | MBS968958 |
| Price | $160, $235 |
| Order / More Info | Human 26S proteasome non-ATPase regulatory subunit 10 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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