Edit |   |
---|---|
Antigenic Specificity | FRS2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: FRS2 Polyclonal Antibody detects endogenous levels of FRS2 protein. FRS2 is a gene on chromosome 12q15 that encodes an adapter protein which links activated FGR and NGF receptors to downstream signalling pathways. Fibroblast growth factor receptor substrate 2 plays a key role in activating MAP kinases and in phosphorylating PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Fibroblast growth factor receptor substrate 2 modulates signalling via SHC1 by competing with it for a common binding site on NTRK1. It is usually part of heteromultimeric protein complexes, and it is highly expressed in the heart, brain, spleen, lungs, liver, skeletal muscle, kidneys and test |
Immunogen | Immunogen: Synthesized peptide derived from human FRS2 around the non-phosphorylation site of Y196 |
Other Names | [Rabbit FRS2; FRS2; Fibroblast growth factor receptor substrate 2; FGFR substrate 2; FGFR-signaling adaptor SNT; Suc1-associated neurotrophic factor target 1; SNT-1] |
Gene, Accession # | [FRS2], Gene ID: 10818, NCBI: NP_001036020.1, UniProt: Q8WU20 |
Catalog # | MBS9702082 |
Price | $130, $220, $325 |
Order / More Info | FRS2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |