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Antigenic Specificity | XEDAR |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mg |
Concentration | 1 mg/mL |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | XEDAR Antibody: X-linked ectodysplasin-A2 receptor (XEDAR) is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and binds to ectodysplatin-A2 (EDA-A2). Two predominantly expressed isoforms, XEDAR-s and XEDAR-L, differ by only a 21-amino region at the juxtamembrane region of the cytoplasmic domain. Neither isoform possesses a death domain and both have been shown to act mainly through TRAF3 and TRAF6 to activate the NF-κB and JNK pathways. Cells transfected with XEDAR and treated with EDA-A2 cause the assembly of a secondary complex containing FADD, caspase-8 and caspase-10, leading to the activation caspase-8 and caspase-3, and finally apoptosis. The EDA-A2-ind |
Immunogen | Immunogen: XEDAR antibody was raised against recombinant human XEDAR. Buffer: XEDAR Antibody is supplied in PBS containing 0.02% sodium azide. |
Other Names | [XEDAR; XEDAR; EDAA2R; EDA-A2R; TNFRSF27; XEDAR; UNQ2448/PRO5727/PRO34080; Tumor necrosis factor receptor superfamily member 27; X-linked ectodysplasin-A2 receptor; EDA-A2 receptor; ectodysplasin A2 receptor], [EDA2R; EDA2R; XEDAR; EDAA2R; EDA-A2R; TNFRSF27; TNFRSF27; XEDAR; EDA-A2 receptor] |
Gene, Accession # | [EDA2R], Gene ID: 60401, NCBI: AAQ89953, UniProt: Q9HAV5 |
Catalog # | MBS151283 |
Price | $375 |
Order / More Info | XEDAR Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |