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Antigenic Specificity | CXCR4 (EL) (HIV and chemokine receptor) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors 1. Among them, CXCR4 (fusin, LESTR or HUMSTR) is a principal coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells2,3. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-24,5. The -chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-16,7. CXCR4 associates with the surface CD4-gp120 com |
Immunogen | Immunogen: Synthetic peptide corresponding to amino acids 182 to 196 of the second extracellular loop of the human CXCR4 receptor. |
Other Names | [CXCR4 (Fusin; LESTR; HUMSTR) (Second Extracellular Loop)], [CXCR4; CXCR4; FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LESTR; NPY3R; NPYRL; HSY3RR; NPYY3R; D2S201E; CXC-R4; CXCR-4; LESTR] |
Gene, Accession # | [CXCR4], Gene ID: 7852, NCBI: NP_001008540.1, UniProt: P61073 |
Catalog # | MBS395780 |
Price | $510 |
Order / More Info | CXCR4 (EL) (HIV and chemokine receptor) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |