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Antigenic Specificity | E-Cadherin |
Clone | [3H11-G1-E0] |
Host Species | Mouse |
Reactive Species | human, mouse, monkey |
Isotype | IgG1 |
Format | ascites |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. In |
Immunogen | Immunogen: Purified recombinant fragment of human CDH1 expressed in E. Coli. |
Other Names | [cadherin-1 isoform 1 preproprotein; Cadherin-1; cadherin-1; cadherin 1; CAM 120/80; Epithelial cadherin; E-cadherin; Uvomorulin] |
Gene, Accession # | [ECAD], Gene ID: 999, NCBI: NP_004351.1, UniProt: P12830 |
Catalog # | MBS8538704 |
Price | $280 |
Order / More Info | E-Cadherin Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |